Functional Neuronal Information and Bioenergetics: The Battery Analogy

🧠 Functional Neuronal Information & Bioenergetics: The Battery Analogy

Imagine a neuron as a battery:

Fully charged → it can process information accurately.

Low charge → the same signal that normally conveys learning can cause damage.

In our ISHEA in silico simulations, we see exactly this:

⚡ Na⁺ and K⁺ provide the energetic substrate (the “battery power”),
🔹 Ca²⁺ carries the actual functional information, activating CaMKII to encode plasticity.

Results:

Healthy neurons generate plastic information under stimulation.

Energy-depleted neurons experience excitotoxic collapse even under the same signal.

Stress can propagate in small networks, mimicking early neurodegenerative processes.

💡 Takeaway: Functional neuronal information depends on energy availability, linking bioelectricity, metabolism, and neuronal health.

*“Unlike classical models that treat ions as mere conductors, ISHEA distinguishes energy from information.”*

This framework is fully reproducible with public data, offering predictive insights into neuronal function and degeneration.

📊 [Insert Ca²⁺ vs CaMKII* graphic with physiologic vs stress coloring + neuron icons]

C.J.Perez Pulido
#ISHEABio

Citation:
Perez Pulido, C.J. (2025). ISHEA Bio: In Silico Validation of Neuronal Bioenergetic-Informational Dynamics.
OSF. DOI: 10.17605/OSF.IO/B7XHE

#Neuroscience #Bioenergetics #CalciumDynamics #Neurodegeneration #ISHEA #InSilicoModeling #Research #ScienceCommunication #ISHEABio #CognitiveSystems