Functional Bioenergetic-Proteic Map: Cellular Coherence Made Visible

🔬 Functional Bioenergetic–Proteic Map – Visualizing Cellular Coherence

Cells are not just energy machines—they are information networks. Our latest preprint visualizes how NAD⁺, ROS, and ATP coordinate bioenergetic coherence and execute cellular functions.

🌀 Two-Level System:

1️⃣ Coherence Layer (informational): NAD⁺ and controlled ROS act as information regulators, organizing electron flow and maintaining metabolic stability.
2️⃣ Execution Layer (energetic): ATP serves as the energy executor, enabling biochemical processes only when upstream coherence is established.

⚡ Key Insights:

• NAD⁺ is the primary driver of system stability.
• ROS is not merely a byproduct—it provides essential feedback for coherence.
• ATP amplifies and executes, but alone cannot restore systemic order.

📊 Why it matters:
In-silico simulations suggest that metabolic resilience depends first on coherence, then on energy availability. This reframes cellular bioenergetics from an “energy-first” model to an information-driven control paradigm.

🖼️ #NASA-style Visualization:
Proteins and bioenergetic molecules form a dynamic functional network, illustrating how perturbations impact coherence and downstream functional execution.

💡 Educational & Systemic Value:
This map enables:

• Understanding metabolic resilience and failure modes
• Exploring interventions aimed at improving systemic coherence
• Integrating energy, redox, and protein networks into a unified functional framework

📌 Takeaway:
Cellular energy systems are best understood through coherence—not just ATP levels.

📄 This preprint (RSID: rs-8899090) is currently under peer review at Scientific Reports (Nature Portfolio).
Developed at the ISHEA Institute by Carlos J. Pérez Pulido.

🔗 Preprint available at:
https://lnkd.in/d8ZEmtMK

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