From bioenergetic synchrony to the narrative hive

This project presents the ISHEA framework — an integrative systems model that bridges genetic regulation, bioenergetic dynamics, and digital phenotyping to understand and enhance human resilience and brain health. Central to the model are Forkhead Box (FOX) transcription factors, which act as "bioenergetic fidelity gates" that translate genetic instructions into neural and behavioral outputs under the energetic constraints imposed by cortisol and mitochondrial function.

The framework is structured around the TACC cycle (Knowledge–Transfer–Assimilation–Creative Action–Resilience), which maps how molecular signals propagate across biological scales to shape adaptive capacity. Disruptions in this flow—due to chronic stress, nutrient imbalance, or circadian misalignment—manifest as measurable changes in digital biomarkers such as heart rate variability (HRV), vocal prosody, and sleep architecture.

This OSF project documents the theoretical foundations, key hypotheses, and proposed validation pathways for non-pharmacological neuroprotection strategies grounded in real-time biofeedback and personalized lifestyle interventions.